nACh subunit a3

Click on sections of picture to learn more about research on individual amino acids. Numbering of the nACh a3 subunit sequences starts at the end of the signal sequence. Only amino acids in the mature protein are shown.

amino acid all M3 M2 M1-M2 Linker M1 M2-M3 Linker N-Terminus M3-M4 Linker M4

nACh a3 -- GENBANK

nACh a3 -- FASTA

nACh a3 -- Alignment

 

 

 

 

 

 

 

 

 

 

 

N-Terminus

Ser 1 Glu 2 Ala 3 Glu 4 His 5 Arg 6 Leu 7 Phe 8 Glu 9 Arg 10 Leu 11 Phe 12 Glu 13 Asp 14 Tyr 15 Asn 16 Gln 17 Ile 18 Ile 19 Arg 20 Pro 21 Val 22 Ala 23 Asn 24 Val 25 Ser 26 Asp 27 Pro 28 Val 29 Ile 30 Ile 31 His 32 Phe 33 Glu 34 Val 35 Ser 36 Met 37 Ser 38 Gln 39 Leu 40 Val 41 Lys 42 Val 43 Asp 44 Glu 45 Val 46 Asn 47 Gln 48 Ile 49 Met 50 Glu 51 Thr 52 Asn 53 Leu 54 Trp 55 Leu 56 Lys 57 Gln 58 Ile 59 Trp 60 Asn 61 Asp 62 Tyr 63 Lys 64 Leu 65 Lys 66 Trp 67 Asn 68 Pro 69 Ser 70 Asp 71 Tyr 72 Gly 73 Gly 74 Ala 75 Glu 76 Phe 77 Met 78 Arg 79 Val 80 Pro 81 Ala 82 Gln 83 Lys 84 Ile 85 Trp 86 Lys 87 Pro 88 Asp 89 Ile 90 Val 91 Leu 92 Tyr 93 Asn 94 Asn 95 Ala 96 Val 97 Gly 98 Asp 99 Phe 100 Gln 101 Val 102 Asp 103 Asp 104 Lys 105 Thr 106 Lys 107 Ala 108 Leu 109 Leu 110 Lys 111 Tyr 112 Thr 113 Gly 114 Glu 115 Val 116 Thr 117 Trp 118 Ile 119 Pro 120 Pro 121 Ala 122 Ile 123 Phe 124 Lys 125 Ser 126 Ser 127 Cys 128 Lys 129 Ile 130 Asp 131 Val 132 Thr 133 Tyr 134 Phe 135 Pro 136 Phe 137 Asp 138 Tyr 139 Gln 140 Asn 141 Cys 142 Thr 143 Met 144 Lys 145 Phe 146 Gly 147 Ser 148 Trp 149 Ser 150 Tyr 151 Asp 152 Lys 153 Ala 154 Lys 155 Ile 156 Asp 157 Leu 158 Val 159 Leu 160 Ile 161 Gly 162 Ser 163 Ser 164 Met 165 Asn 166 Leu 167 Lys 168 Asp 169 Tyr 170 Trp 171 Glu 172 Ser 173 Gly 174 Glu 175 Trp 176 Ala 177 Ile 178 Ile 179 Lys 180 Ala 181 Pro 182 Gly 183 Tyr 184 Lys 185 His 186 Asp 187 Ile 188 Lys 189 Tyr 190 Asn 191 Cys 192 Cys 193 Glu 194 Glu 195 Ile 196 Tyr 197 Pro 198 Asp 199 Ile 200 Thr 201 Tyr 202 Ser 203 Leu 204 Tyr 205 Ile 206 Arg 207 Arg 208 Leu 209

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M1

Pro 235 Leu 234 Tyr 233 Phe 232 Val 231 Leu 230 Val 229 Thr 228 Leu 227 Phe 226 Ser 225 Ile 224 Leu 223 Leu 222 Cys 221 Pro 220 Ile 219 Leu 218 Leu 217 Asn 216 Ile 215 Thr 214 Tyr 213 Phe 212 Leu 211 Pro 210

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M1-M2 Linker

Ser 236 Asp 237 Cys 238 Gly 239 Glu 240 Lys 241

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M2

Val 242 Thr 243 Leu 244 Cys 245 Ile 246 Ser 247 Val 248 Leu 249 Leu 250 Ser 251 Leu 252 Thr 253 Val 254 Phe 255 Leu 256 Leu 257 Val 258 Ile 259 Thr 260 Glu 261 Thr 262 Ile 263 Pro 264

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M2-M3 Linker

Ser 265 Thr 266 Ser 267 Leu 268 Val 269 Ile 270

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M3

Pro 271 Leu 272 Ile 273 Gly 274 Glu 275 Tyr 276 Leu 277 Leu 278 Phe 279 Thr 280 Met 281 Ile 282 Phe 283 Val 284 Thr 285 Leu 286 Ser 287 Ile 288 Val 289 Ile 290 Thr 291 Val 292 Phe 293 Val 294 Leu 295

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M3-M4 Linker

Lys 438 Trp 437 Asp 436 Asp 435 Gln 434 Ile 433 Glu 432 Lys 431 Ala 430 Glu 429 Asn 428 Gln 427 Ala 426 Lys 425 Met 424 Asn 423 Glu 422 Ala 421 Ile 420 Tyr 419 Lys 418 Val 417 Ser 416 Gln 415 Ile 414 Ala 413 Glu 412 Lys 411 Ile 410 Glu 409 Pro 408 Ser 407 Leu 406 Ala 405 Ser 404 Leu 403 Ser 402 Leu 401 Val 400 Ala 399 Asp 398 Val 397 Ser 396 Glu 395 Ser 394 Ser 393 Ser 392 Ser 391 Arg 390 Thr 389 Leu 388 Asn 387 Ala 386 Ser 385 Phe 384 Asn 383 Ser 382 Ile 381 Lys 380 Ile 379 Arg 378 Arg 377 His 376 His 375 Cys 374 Tyr 373 Gly 372 Cys 371 Met 370 Gly 369 Asp 368 Gln 367 Cys 366 Pro 365 Tyr 364 Gly 363 Glu 362 Lys 361 Cys 360 Gly 359 Lys 358 Ser 357 Glu 356 Ala 355 Arg 354 Ser 353 Phe 352 Cys 351 Asn 350 Leu 349 Asn 348 Ser 347 Leu 346 Glu 345 Ala 344 Gly 343 Tyr 342 Leu 341 Pro 340 Arg 339 Pro 338 Lys 337 Gln 336 Ala 335 Asn 334 Gly 333 Glu 332 Asn 331 Ser 330 Thr 329 Pro 328 Arg 327 Thr 326 Met 325 Phe 324 Met 323 Val 322 Arg 321 Pro 320 Leu 319 Leu 318 Asn 317 Leu 316 Phe 315 Val 314 Thr 313 Lys 312 Val 311 Trp 310 Ser 309 Pro 308 Met 307 Thr 306 His 305 Thr 304 Thr 303 Pro 302 Thr 301 Arg 300 Tyr 299 His 298 Val 297 Asn 296

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M4

Tyr 439 Val 440 Ala 441 Met 442 Val 443 Ile 444 Asp 445 Arg 446 Ile 447 Phe 448 Leu 449 Trp 450 Val 451 Phe 452 Thr 453 Leu 454 Val 455 Cys 456 Ile 457 Leu 458 Gly 459 Thr 460 Ala 461 Glu 462 Leu 463 Phe 464 Leu 465 Gln 466 Pro 467 Leu 468 Met 469 Ala 470 Arg 471 Glu 472 Asp 473 Ala 474

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Alignment

N-Terminus First Membrane Spanning Second Membrane Spanning Third Membrane Spanning Outside the Cell Inside the Cell C-Terminus