nACh subunit a1

Click on sections of picture to learn more about research on individual amino acids. Numbering of the nACh a1 subunit sequences starts at the end of the signal sequence. Only amino acids in the mature protein are shown.


amino acid all M3 M2 M1-M2 Linker M1 M2-M3 Linker N-Terminus M3-M4 Linker M4

nACh a1 - GENBANK

nACh a1 - FASTA

nACh a1 - Alignment

 

 

 

 

 

 

 

 

 

 

 

N-Terminus

Arg 1 Gln 2 Val 3 Val 4 Glu 5 Val 6 Thr 7 Val 8 Gly 9 Leu 10 Gln 11 Leu 12 Ile 13 Gln 14 Leu 15 Ile 16 Asn 17 Val 18 Asp 19 Glu 20 Val 21 Asn 22 Gln 23 Ile 24 Val 25 Thr 26 Thr 27 Asn 28 Val 29 Arg 30 Leu 31 Lys 32 Gln 33 Gly 34 Asp 35 Met 36 Val 37 Asp 38 Leu 39 Pro 40 Arg 41 Pro 42 Ser 43 Cys 44 Val 45 Thr 46 Leu 47 Gly 48 Val 49 Pro 50 Leu 51 Phe 52 Ser 53 His 54 Leu 55 Gln 56 Asn 57 Glu 58 Gln 59 Trp 60 Tyr 61 Asp 62 Tyr 63 Asn 64 Leu 65 Lys 66 Trp 67 Asn 68 Pro 69 Asp 70 Asp 71 Tyr 72 Gly 73 Gly 74 Val 75 Lys 76 Lys 77 Ile 78 His 79 Ile 80 Pro 81 Ser 82 Glu 83 Lys 84 Ile 85 Trp 86 Arg 87 Pro 88 Asp 89 Leu 90 Val 91 Leu 92 Tyr 93 Asn 94 Asn 95 Ala 96 Asp 97 Gly 98 Asp 99 Phe 100 Ala 101 Ile 102 Val 103 Lys 104 Phe 105 Thr 106 Lys 107 Val 108 Leu 109 Leu 110 Gln 111 Tyr 112 Thr 113 Gly 114 His 115 Ile 116 Thr 117 Trp 118 Thr 119 Pro 120 Pro 121 Ala 122 Ile 123 Phe 124 Lys 125 Ser 126 Tyr 127 Cys 128 Glu 129 Ile 130 Ile 131 Val 132 Thr 133 His 134 Phe 135 Pro 136 Phe 137 Glu 138 Gln 139 Asn 140 Cys 141 Ser 142 Met 143 Lys 144 Leu 145 Gly 146 Thr 147 Trp 148 Thr 149 Tyr 150 Asp 151 Gly 152 Ser 153 Val 154 Val 155 Ala 156 Ile 157 Asn 158 Pro 159 Glu 160 Ser 161 Asp 162 Gln 163 Pro 164 Asp 165 Leu 166 Ser 167 Asn 168 Phe 169 Met 170 Glu 171 Ser 172 Gly 173 Glu 174 Trp 175 Val 176 Ile 177 Lys 178 Glu 179 Ser 180 Arg 181 Gly 182 Trp 183 Lys 184 His 185 Ser 186 Val 187 Thr 188 Tyr 189 Ser 190 Cys 191 Cys 192 Pro 193 Asp 194 Thr 195 Pro 196 Tyr 197 Leu 198 Asp 199 Ile 200 Thr 201 Tyr 202 His 203 Phe 204 Val 205 Met 206 Gln 207 Arg 208 Leu 209 Pro 210
Residues with mutations: [ Val 132 ]

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M1

Tyr 233 Phe 232 Val 231 Leu 230 Gly 229 Thr 228 Leu 227 Phe 226 Ser 225 Phe 224 Leu 223 Leu 222 Cys 221 Pro 220 Ile 219 Ile 218 Val 217 Asn 216 Val 215 Ile 214 Tyr 212 Phe 213 Leu 211

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M1-M2 Linker

Leu 234 Pro 235 Thr 236 Asp 238 Ser 239 Gly 240 Glu 241 Lys 242

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M2

Met 243 Thr 244 Leu 245 Ser 246 Ile 247 Ser 248 Val 249 Leu 250 Leu 251 Ser 252 Leu 253 Thr 254 Val 255 Phe 256 Leu 257 Leu 258 Val 259 Ile 260 Val 261

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M2-M3 Linker

Glu 262 Leu 266 Ile 264 Pro 265 Ser 266 Thr 267 Ser 268 Ser 269 Ala 270 Val 271

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M3


Residues with mutations: [ Val 285 ]

Pro 272 Leu 273 Ile 274 Gly 275 Lys 276 Tyr 277 met 278 Leu 279 Phe 280 Thr 281 Met 282 Val 283 Phe 284 Val 285 Ile 286 Ala 287 Ser 288 Ile 289 Ile 290

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M3-M4 Linker

Gly 412 Leu 411 Leu 410 Ile 409 His 408 Asp 407 Met 406 Val 404 Met 404 Ala 403 Val 402 Tyr 401 Lys 400 Trp 399 Glu 398 Ala 397 Ala 396 Ala 395 Asn 394 Asn 393 Ser 392 Glu 391 Gln 390 Asp 389 Ser 388 Lys 387 Met 386 Thr 385 Glu 384 Ala 383 Ile 382 Tyr 381 Lys 380 Ile 379 Gly 378 Glu 377 Ile 376 Ala 375 Ser 374 Lys 373 Val 372 Glu 371 Pro 370 His 369 Lys 368 Ile 367 Leu 366 Pro 365 Ser 364 His 363 Phe 362 Gly 361 Met 360 Pro 359 Pro 358 Pro 357 Gly 356 Pro 355 Lys 354 Gly 353 Ser 352 Ile 351 Asp 350 Ser 349 Ile 348 Asp 347 Ile 346 Asp 345 Glu 344 Thr 343 Phe 342 Ile 341 Lys 340 Lys 339 Asp 338 Gln 337 Lys 336 Glu 335 Arg 334 Ser 333 Pro 332 Arg 331 Lys 330 Met 329 Thr 328 Ser 327 Phe 326 Phe 325 Met 324 Ile 323 Asn 322 Pro 321 Ile 320 Thr 319 Asp 318 Ile 317 Phe 316 Val 315 Lys 314 Arg 313 Val 312 Trp 311 Asn 310 Pro 309 Met 308 Val 307 His 306 Thr 305 Ser 304 Pro 303 Ser 302 Arg 301 His 300 His 299 Thr 298 Asn 297 Ile 296 Val 295 Ile 294 Val 293 Thr 292 Ile 291

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M4

Val 413 Phe 414 Met 415 Leu 416 Val 417 Cys 418 Ile 419 Ile 420 Gly 421 Thr 422 Leu 423 Ala 424 Val 425 Phe 426 Ala 427 Gly 428 Arg 429 Leu 430 Ile 431 Glu 432 Leu 433 Asn 434 Gln 435 Gln 436 Gly 437

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Alignment

N-Terminus First Membrane Spanning Second Membrane Spanning Third Membrane Spanning Outside the Cell Inside the Cell C-Terminus