nACh subunit b2

nACh Receptor Description


amino acid all M1 N-Terminus M1-M2 Linker M3 M4 M2 M3-M4 Linker M2-M3 Linker Click on sections of picture to learn more about research on individual amino acids.

Numbering of the nACh b2 subunit sequences start at the beginning of the signal sequence. Only amino acids in the mature protein are shown.

 

nACh b2 -- GENBANK

nACh b2 -- FASTA

nACh b2 -- Alignment

 

 

 

 

N-Terminus

Asp 27 Thr 28 Glu 29 Glu 30 Arg 31 Leu 32 Val 33 Glu 34 His 35 Leu 36 Leu 37 Asp 38 Pro 39 Ser 40 Arg 41 Tyr 42 Asn 43 Lys 44 Leu 45 Ile 46 Arg 47 Pro 48 Ala 49 Thr 50 Asn 51 Gly 52 Ser 53 Glu 54 Leu 55 Val 56 Thr 57 Val 58 Gln 59 Leu 60 Met 61 Val 62 Ser 63 Leu 64 Ala 65 Gln 66 Leu 67 Ile 68 Ser 69 Val 70 His 71 Glu 72 Arg 73 Glu 74 Gln 75 Ile 76 Met 77 Thr 78 Thr 79 Asn 80 Val 81 Trp 82 Leu 83 Thr 84 Gln 85 Glu 86 Trp 87 Glu 88 Asp 89 Tyr 90 Arg 91 Leu 92 Thr 93 Trp 94 Lys 95 Pro 96 Glu 97 Glu 98 Phe 99 Asp 100 Asn 101 Met 102 Lys 103 Lys 104 Val 105 Arg 106 Leu 107 Pro 108 Ser 109 Lys 110 His 111 Ile 112 Trp 113 Leu 114 Pro 115 Asp 116 Val 117 Val 118 Leu 119 Tyr 120 Asn 121 Asn 122 Ala 123 Asp 124 Gly 125 Met 126 Tyr 127 Glu 128 Val 129 Ser 130 Phe 131 Tyr 132 Ser 133 Asn 134 Ala 135 Val 136 Val 137 Ser 138 Tyr 139 Asp 140 Gly 141 Ser 142 Ile 143 Phe 144 Trp 145 Leu 146 Pro 147 Pro 148 Ala 149 Ile 150 Tyr 151 Lys 152 Ser 153 Ala 154 Cys 155 Lys 156 Ile 157 Glu 158 Val 159 Lys 160 His 161 Phe 162 Pro 163 Phe 164 Asp 165 Gln 166 Gln 167 Asn 168 Cys 169 Thr 170 Met 171 Lys 172 Phe 173 Arg 174 Ser 175 Trp 176 Thr 177 Tyr 178 Asp 179 Arg 180 Thr 181 Glu 182 Ile 183 Asp 184 Leu 185 Val 186 Leu 187 Lys 188 Ser 189 Glu 190 Val 191 Ala 192 Ser 193 Leu 194 Asp 195 Asp 196 Phe 197 Thr 198 Pro 199 Ser 200 Gly 201 Glu 202 Trp 203 Asp 204 Ile 205 Val 206 Ala 207 Leu 208 Pro 209 Gly 210 Arg 211 Arg 212 Asn 213 Glu 214 Asn 215 Pro 216 Asp 217 Asp 218 Ser 219 Thr 220 Tys 221 Val 222 Asp 223 Ile 224 Thr 225 Tyr 226 Asp 227 Phe 228 Ile 229 Ile 230 Arg 231 Arg 232 Lys 233 Pro 234 back to top

 

M1

Tyr 257 Phe 256 Val 255 Leu 254 Ile 253 Ala 252 Leu 251 Ser 250 Thr 249 Ile 248 Leu 247 Val 246 Cys 245 Pro 244 Ile 243 Ile 242 Leu 241 Asn 240 Ile 239 Thr 238 Tyr 237 Phe 236 Leu 235

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M1-M2 Linker

Leu 258 Pro 259 Ser 260 Asp 261 Cys 262 Gly 263 Glu 264 Lys 265

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M2

Met 266 Thr 267 Leu 268 Cys 269 Ile 270 Ser 271 Val 272 Leu 273 Leu 274 Ala 275 Leu 276 Thr 277 Val 278 Phe 279 Leu 280 Leu 281 Leu 282 Ile 283 Ser 284

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M2-M3 Linker

Lys 285 Ile 286 Val 287 Pro 288 Pro 289 Thr 290 Ser 291 Leu 292 Asp 293 Val 294
Residues with mutations: [ Val 287 ]

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M3

Pro 295 Leu 296 Val 297 Gly 298 Lys 299 Tyr 300 Leu 301 Met 302 Phe 303 Thr 304 Met 305 Val 306 Leu 307 Val 308 Thr 309 Phe 310 Ser 311 Ile 312 Val 313

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M3-M4 Linker

Trp 464 Leu 463 Phe 462 Leu 461 Arg 460 Asp 459 Ile 458 Val 457 Met 456 Ala 455 Val 454 Tyr 453 Lys 452 Trp 451 Asp 450 Glu 449 Ser 448 Val 447 Ser 446 Gln 445 Asp 444 Asp 443 Asp 442 Glu 441 Ser 440 Arg 439 Met 438 His 437 Asp 436 Ala 435 Ile 434 Phe 433 Arg 432 Val 431 Gly 430 Asp 429 Val 428 Ala 427 Glu 426 Arg 425 Leu 424 Gly 423 Cys 422 Gly 421 Cys 420 Pro 419 Glu 418 Gly 417 Ser 416 Arg 415 Gly 414 Pro 413 Gly 412 Ala 411 Val 410 Pro 409 Ala 408 Pro 407 Glu 406 Ala 405 Gly 404 Phe 403 Ala 402 Gly 401 Ala 400 Leu 399 Gly 398 Gln 397 Val 396 Ser 395 Ala 394 Arg 393 Asn 392 Val 391 Phe 390 Cys 389 Thr 388 Cys 387 Ser 386 Asp 385 Ala 384 Gly 383 Pro 382 Ala 381 Glu 380 Arg 379 Phe 378 Phe 377 Leu 376 Ala 375 Gly 374 Ala 373 Gly 372 Glu 371 Arg 370 Glu 369 Arg 368 Gln 367 Arg 366 Arg 365 Arg 364 Leu 363 Arg 362 Leu 361 Arg 360 Gln 359 Arg 358 Ala 357 Cys 356 His 355 His 354 Arg 353 Pro 352 Gln 351 Gln 350 Met 349 Phe 348 Leu 347 Leu 346 Ala 345 Pro 344 Leu 343 Lys 342 Glu 341 Leu 340 Phe 339 Val 338 Val 337 Lys 336 Val 335 Trp 334 Pro 333 Ala 332 Met 331 Thr 330 His 329 Thr 328 Thr 327 Pro 326 Ser 325 Arg 324 His 323 His 322 Val 321 Asn 320 Leu 319 Val 318 Cys 317 Val 316 Ser 315 Thr 314
Residues with mutations: [ Glu 441 ] [ Gln 445 ] [ Glu 449 ]

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M4

Ile 465 Phe 466 Val 467 Phe 468 Val 469 Cys 470 Val 471 Phe 472 Gly 473 Thr 474 Ile 475 Gly 476 Met 477 Phe 478 Leu 479 Gln 480 Pro 481 Leu 482 Phe 483 Gln 484 Asn 485 Tyr 486 Thr 487 Thr 488 Thr 489 Thr 490 Phe 491 Leu 492 His 493 Ser 494 Asp 495 His 496 Ser 497 Ala 498 Pro 499 Ser 500 Ser 501 Lys 502

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Alignment

N-Terminus First Membrane Spanning Second Membrane Spanning Third Membrane Spanning Outside the Cell Inside the Cell C-Terminus