Human nACh b2 -- Gln 445

Species Original Mutated to Mutation
Human Gln 445    
Rat Equivalent Gln 443 Arg

Q443R

Mouse Equivalent Gln 442    

rGln443Arg

This mutation had little effect on the single-channel conductance. When it was combined with R436D, the double mutation produced conductance that was greater than the sum of the individual mutations. When it was combined with R440A, there was no such synergy. In a triple mutation of R432Q, R436D, and R440A, the single-channel conductance increased substantially.

Hales TG, Dunlop JI, Deeb TZ, Carland JE, Kelley SP, Lambert JJ, Peters JA (2006) Common determinants of single channel conductance within the large cytoplasmic loop of 5-HT3 and alpha 4beta 2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry [Epub ahead of print]

 

See Equivalent Mutation in R436D

 

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