Human 5-HT3A -- Trp 209

Species Original Mutated to Mutation
Human Trp 209  

 

Rat Equivalent Trp 208    
Mouse Equivalent Trp 214

Tyr

Ser

W214Y

W214S

 

mTrp214Tyr

The mutant did not bind [3H]granisetron or [3H]mCPBG. There was no electrophysiological response to high concentrations of 5-HT.

 

Spier AD, Lumis SCR (2000) The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain. The Journal of Biological Chemistry 275(8): 5620-5625

 

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mTrp214Ser

 

The mutant did not bind [3H]granisetron or [3H]mCPBG. There was no electrophysiological response to high concentrations of 5-HT.

 

Spier AD, Lumis SCR (2000) The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain. The Journal of Biological Chemistry 275(8): 5620-5625

 

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