Human 5-HT3A -- Trp 116

Species Original Mutated to Mutation
Human Trp 116  

 

Rat Equivalent Trp 115    
Mouse Equivalent Trp 121

Tyr

Ser

W121Y

W121S

 

mTrp121Tyr

No specific binding of either [3H]granisetron or [3H]mCPBG was observed with this mutant. No response to high concentrations of 5-HT.

 

Spier AD, Lumis SCR (2000) The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain. The Journal of Biological Chemistry 275(8): 5620-5625

 

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mTrp121Ser

No specific binding of either [3H]granisetron or [3H]mCPBG was observed with this mutant. No response to high concentrations of 5-HT.

 

Spier AD, Lumis SCR (2000) The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain. The Journal of Biological Chemistry 275(8): 5620-5625

 

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