Human 5-HT3A -- Arg 344

Species Original Mutated to Mutation
Human Arg 344 His R344H
Rat Equivalent Arg 343    
Mouse Equivalent

Arg 349

   

hArg344His

Mutation in the human 5-HT3A receptor residues Pro391Arg and Arg344His has been found in patients with schizophrenic and bipolar affective disorder. Function of this mutation is unknown.

Niesler B.,Weiss B.,Fischer C.,Nothen M M., Propping P.,Bondy B.,Rietschel M.,Maier W.,Albus M.,Franzek E.,and Rappold G A. (2001) Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients. Pharmacogenetics 11:21-27

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