Human 5-HT3A -- Pro 51

Species Original Mutated to Mutation
Human Pro 51  

 

Rat Equivalent Pro 50    
Mouse Equivalent Pro 56 Ala P56A

 

mPro56Ala

Mutation resulted in the ablation of specific binding. No labeling was observed when their localization was studied using an antiserum specific for the N terminus of the 5-HT3A.

Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966

 

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