Human 5-HT3A -- Pro 296
|Rat Equivalent||Pro 295|
|Mouse Equivalent||Pro 301||Ala||P301A|
Specific Binding of [3H]granisetron revealed Kd values of 0.20+/- 0.07nM. Using pAb120, the mutant receptor was shown to be localized on the cell surface, however they were non-functional when using whole cell patch clamp.
Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966
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