Human 5-HT3A -- Phe 166

Species Original Mutated to Mutation
Human Phe 166  

 

Rat Equivalent Phe 165    
Mouse Equivalent Phe 171

Pro

Asp

F171P

F171D

 

mPhe171Pro

5-HT3 specific ligands bound to this mutant receptor.

 

Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966

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mPhe171Asp

5-HT3 specific ligands failed to bind to this mutant receptor.

Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966

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go back to 5-HT3A

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