Human 5-HT3A -- Phe 164

Species Original Mutated to Mutation
Human Phe 164  

 

Rat Equivalent Phe 163    
Mouse Equivalent Phe 169

Gly

Ile

F169G

F169I

 

mPhe169Gly

The mutant exhibited 5-HT3 receptor specific binding.

 

Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966

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mPhe169Ile

The mutant lacked 5-HT3 receptor specific binding .

Deane CM, Lummis SCR (2001) The Role and Predicted Propensity of Conserved Proline Residues in the 5-HT3 Receptor. The Journal of Biological Chemistry 276(41):37962-37966

 

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go back to 5-HT3A

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