Human 5-HT3A -- Ala 297

Species Original Mutated to Mutation
Human Ala 297
(A24'K)
Lys

A297K

Rat Equivalent Ala 298    
Mouse Equivalent Ala 302    

 

hAla297K

No functional receptors were detected as a result of this mutation, even when it was combined with E272A or S292R (EA, SR, or EASR.) High levels of binding were found with the antagonist granisetron. The dissociation constants were similar to those for the WT. The 5-HT3 receptors were expressed at the plasma membrane.

 

Thompson AJ, Lummis SCR (2003) A Single Ring of Charged Amino Acids at One End of the Pore Can Control Ion Selectivity in the 5-HT3 Receptor. British Journal of Pharmaoclogy 140(s) 359-365

 

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